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The targets for Zn-mediated impact on energy metabolism may include PPARs (proliferator-activated receptors), which are responsible for the expression of mRNA genes that play a critical role in energy metabolism [98, 99]

Changes in hypothalamic Kiss1 and Gnrh1 and pituitary Lhb mRNA and circulating LH levels On PND24, hypothalamic Kiss1 and Gnrh1 mRNA levels of rhGH rats were significantly higher than those of control rats, the hypothalamic Kiss1 and Gnrh1 mRNA levels of 2 IU/kg rhGH rats were significantly higher than those of 1 IU/kg rhGH rats on PND 24

[DOI] [PubMed] [Google Scholar] 66.Bhatt A.P., Gunasekara D.B., Speer J., Reed M.I., Pea A.N., Midkiff B.R., Magness S.T., Bultman S.J., Allbritton N.L., Redinbo M.R